Article
The role of genetic variants of Stromal cell-Derived Factor 1 in pediatric HIV-1 infection and disease progression.
PloS one - 1 Jan 2012
Gianesin Ketty, Freguja Riccardo, Carmona Francesco, Zanchetta Marisa, Del Bianco Paola, Malacrida Sandro, Montagna Marco, Rampon Osvalda, Giaquinto Carlo, De Rossi Anita
Abstract excerpt
Stromal cell-Derived Factor 1 (SDF1) is the natural ligand of CXCR4, the coreceptor of HIV-1 X4 viruses. This study investigated the role of the single nucleotide polymorphism (SNP) rs1801157 (NM_000609.5:c.*519G>A) of the SDF1 gene in the natural history of mother-to-child transmission of HIV-1 and disease progression of HIV-1-infected children. The study was conducted in 428 children born to HIV-1-seropositive...
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