Article
CUL5 and APOBEC3G Polymorphisms are Partially Implicated in HIV-1 Infection and Antiretroviral Therapy in a Brazilian Population.
Current HIV research - 1 Jan 2017
da Silva Ronaldo Celerino, Coelho Antonio Victor Campos, de Moura Ronald Rodrigues, Arraes Luiz Cláudio, Brandão Lucas André Cavalcanti, Guimarães Rafael Lima, Crovella Sérgio
Abstract excerpt
BACKGROUND: Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. OBJECTIVE AND METHOD: We evaluated the distribution of single nucleotide polymorphisms (SNPs) in APOBEC3G (rs3736685, rs2294367) and CUL5 (rs7117111, rs7103534, rs11212495) genes, among 264 HIV-1 infected (HIV-1+) and 259 unexposed- uninfected individuals from Northeast Brazil, looking...