Article
Expression of APOBEC3G/3F and G-to-A hypermutation levels in HIV-1-infected children with different profiles of disease progression.
PloS one - 1 Jan 2011
Amoêdo Nívea D, Afonso Adriana O, Cunha Sílvia M, Oliveira Ricardo H, Machado Elizabeth S, Soares Marcelo A
Abstract excerpt
OBJECTIVE: Increasing evidence has accumulated showing the role of APOBEC3G (A3G) and 3F (A3F) in the control of HIV-1 replication and disease progression in humans. However, very few studies have been conducted in HIV-infected children. Here, we analyzed the levels of A3G and A3F expression and induced G-to-A hypermutation in a group of children with distinct profiles of disease progression....
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