Article
Genetic variants in the host restriction factor APOBEC3G are associated with HIV-1-related disease progression and central nervous system impairment in children.
Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2013
Singh Kumud K, Wang Yan, Gray Kathryn P, Farhad Mona, Brummel Sean, Fenton Terence, Trout Rodney, Spector Stephen A
Abstract excerpt
BACKGROUND: Apolipoprotein B mRNA editing catalytic polypeptide 3G (APOBEC3G) protein is incorporated into nascent virus particles and mediates cytidine deamination (C-to-U) of first-strand reverse transcripts of HIV-1 in target cells resulting in G-to-A hypermutation of the coding strand and premature degradation. We investigated the effects of APOBEC3G genetic variants on HIV-1-related disease in children....
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