Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.

PLoS genetics - 1 Mar 2016

An Ping, Penugonda Sudhir, Thorball Christian W, Bartha Istvan, Goedert James J, Donfield Sharyne, Buchbinder Susan, Binns-Roemer Elizabeth, Kirk Gregory D, Zhang Wenyan, Fellay Jacques, Yu Xiao-Fang, Winkler Cheryl A

Abstract excerpt

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However, HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro APOBEC3F (A3F) anti-HIV-1 activity is weaker than A3G but is partially resistant to Vif degradation unlike A3G. It is unknown whether A3F protein affects HIV-1 disease in vivo. To assess the effect of A3F gene on host susceptibility to HIV-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosine Deaminase
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to HIV Infections

Share to Pneumonia, Pneumocystis

Share to Protein Binding

Share to vif Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 26942578
DOI: 10.1371/journal.pgen.1005921
PMCID: PMC4778847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.PMID 26942578Read ↗

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeuticsSemantic proximity Read ↗

Leveraging APOBEC3 Proteins to Alter the HIV Mutation Rate and Combat AIDSSemantic proximity Read ↗

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them AllSemantic proximity Read ↗

Human APOBEC3 Variations and Viral InfectionSemantic proximity Read ↗

APOBEC3G genetic variants and their influence on the progression to AIDS.Semantic proximity Read ↗

A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication.Semantic proximity Read ↗

Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 DiversificationSemantic proximity Read ↗

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.Semantic proximity Read ↗

Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.Semantic proximity Read ↗

Identification of the HIV-1 Vif and Human APOBEC3G Protein InterfaceSemantic proximity Read ↗

Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.Semantic proximity Read ↗

Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.