Article
Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease.
Leukemia - 1 Jun 2012
Miedema K G E, Tissing W J E, Te Poele E M, Kamps W A, Alizadeh B Z, Kerkhof M, de Jongste J C, Smit H A, de Pagter A P, Bierings M, Boezen H M, Postma D S, de Bont E S J M, Koppelman G H
Abstract excerpt
Little is known about the etiology of childhood acute lymphoblastic leukemia (ALL). The presence of atopic disease has been shown to protect against developing childhood ALL. The aim of this study was to examine whether single nucleotide polymorphisms (SNPs) in innate immunity genes previously associated with atopic disease, can elucidate the inverse association between childhood ALL and atopic disease. We...
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