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IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children.

Cancer - 15 Mar 2024

Yang Xu, Yang Lihua, Luo Annie, Liu Shanshan, Zhang Xiaohong, Liu Xiaoping, Liu Xiaodan, Luo Ailing, Cai Mansi, Yan Yaping, Wu Xuedong, Huang Ke, Xu Ling, Jiang Hua

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. IKZF3 (IKAROS family zinc finger 3) is a hematopoietic-specific transcription factor, and it has been validated that it is involved in leukemia. However, the role of IKZF3 single-nucleotide polymorphisms (SNPs) remains unclear. In this case-control study, the authors investigated the association of IKZF3 SNPs with ALL in...

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PMID: 38018448
DOI: 10.1002/cncr.35129

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