Article
Polymorphisms in innate immunity genes and risk of childhood leukemia.
Human immunology - 1 Jul 2010
Han Sohee, Lan Qing, Park Ae Kyung, Lee Kyoung-Mu, Park Sue K, Ahn Hyo Seop, Shin Hee Young, Kang Hyoung Jin, Koo Hong Hoe, Seo Jong Jin, Choi Ji Eun, Ahn Yoon-Ok, Chanock Stephen J, Kim Ho, Rothman Nathaniel, Kang Daehee
Abstract excerpt
The immune system plays an important role in the control of cancer development. To investigate possible genetic contribution to childhood leukemia risk in the innate immune system, we performed an association study for the 1214 SNPs in 146 gene regions related to innate immunity using GoldenGate (Illumina) oligonucleotide pool assay (OPA) in 106 case patients and 123 controls. Childhood leukemia risk was...
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