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Article

Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon.

Scientific reports - 10 May 2021

Alves Fabíola Silva, Xabregas Lilyane Amorim, Kerr Marlon Wendell Athaydes, Souza Gláucia Lima, Pereira Daniele Sá, Magalhães-Gama Fábio, Santiago Mirian Rodrigues Ribeiro, Garcia Nadja Pinto, Tarragô Andréa Monteiro, Ogusku Maurício Morishi, Sadahiro Aya, Malheiro Adriana, Costa Allyson Guimarães

Abstract excerpt

The immune system plays an important role in the control of cancer development. To investigate the possible association of inflammasome genes to childhood leukemia we performed a case-control study with 158 patients with acute lymphoblastic leukemia and 192 healthy individuals. The IL1B and IL18 genetic polymorphisms were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP)...

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Identifiers

PMID: 33972620
DOI: 10.1038/s41598-021-89310-4
PMCID: PMC8110953

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