Clinical Implication of SNVs in TLR Genes in Pediatric Patients From the Brazilian Amazon With Acute Lymphoblastic Leukemia

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy and the leading cause of childhood mortality. Single-nucleotide variants (SNVs) in key molecules of the immune system, such as Toll-like receptors (TLRs) and CD14 molecule, are associated with the development of several diseases. However, their role in ALL is unknown. A case-control study was performed with 152 ALL patients and 187 health...

Topics

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• Brazil
• Case-Control Studies
• Child
• Precursor Cell Lymphoblastic Leukemia-Lymphoma
• Toll-Like Receptor 1
• Toll-Like Receptor 6
• Toll-Like Receptor 9
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

c3453d83-ba06-5fd6-83a8-93d212319c7a

DOI

10.21203/rs.3.rs-1389923/v1