Article
Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia.
Leukemia - 1 Jun 2011
Miedema K G E, te Poele E M, Tissing W J E, Postma D S, Koppelman G H, de Pagter A P, Kamps W A, Alizadeh B Z, Boezen H M, de Bont E S J M
Abstract excerpt
Infections are a major cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). Susceptibility to infections increases as the neutrophil count decreases. Despite identical treatment patients vary considerably in the number of neutropenic episodes. Toll-like receptor 4 (TLR4) has been shown to have a role in inhibiting apoptosis of neutrophils. Therefore, we hypothesized that...
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