Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men.

doi:10.1007/s00223-011-9532-y

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Article

Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men.

Calcified tissue international - 1 Dec 2011

Roshandel Delnaz, Holliday Kate L, Pye Stephen R, Ward Kate A, Boonen Steven, Vanderschueren Dirk, Borghs Herman, Huhtaniemi Ilpo T, Adams Judith E, Bartfai Gyorgy, Casanueva Felipe F, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Han Thang S, Kula Krzysztof, Lean Michael E, Pendleton Neil, Punab Margus, Silman Alan J, Wu Frederick C, Thomson Wendy, ONeill Terence W

Abstract excerpt

We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) ≥ 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG strongly associated with areal BMD in genomewide association studies were previously...

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PMID: 21964949
DOI: 10.1007/s00223-011-9532-y
PMCID: PMC3215872

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Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men.PMID 21964949Read ↗

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