The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.

doi:10.1371/journal.pone.0022037

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Article

The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.

PloS one - 1 Jan 2011

Holliday Kate L, Pye Stephen R, Thomson Wendy, Boonen Steven, Borghs Herman, Vanderschueren Dirk, Gielen Evelien, Huhtaniemi Ilpo T, Adams Judith E, Ward Kate A, Bartfai Gyorgy, Casanueva Felipe, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Han Thang S, Kula Krzysztof, Labrie Fernand, Lean Michael E J, Pendleton Neil, Punab Margus, Wu Frederick C W, O'Neill Terence W

Abstract excerpt

PURPOSE: Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor α gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar spine. The aim of this study was to determine the influence of this locus on other bone health outcomes; calcaneal ultrasound (QUS) parameters, radial peripheral quantitative computed tomography...

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PMID: 21760950
DOI: 10.1371/journal.pone.0022037
PMCID: PMC3131390

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ESR1

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