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Article

Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.

PLoS genetics - 1 Jan 2013

Paternoster Lavinia, Lorentzon Mattias, Lehtimäki Terho, Eriksson Joel, Kähönen Mika, Raitakari Olli, Laaksonen Marika, Sievänen Harri, Viikari Jorma, Lyytikäinen Leo-Pekka, Mellström Dan, Karlsson Magnus, Ljunggren Osten, Grundberg Elin, Kemp John P, Sayers Adrian, Nethander Maria, Evans David M, Vandenput Liesbeth, Tobias Jon H, Ohlsson Claes

Abstract excerpt

Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits as analysed by...

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Identifiers

PMID: 23437003
DOI: 10.1371/journal.pgen.1003247
PMCID: PMC3578773

Genes

GREM2
FMN2
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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