Article
Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2012
Karasik David, Cheung Ching Lung, Zhou Yanhua, Cupples L Adrienne, Kiel Douglas P, Demissie Serkalem
Abstract excerpt
Multiple musculoskeletal traits assessed by various methods at different skeletal sites serve as surrogates for osteoporosis risk. However, it is a challenge to select the most relevant phenotypes for genetic study of fractures. Principal component analyses (PCA) were conducted in participants of the Framingham Osteoporosis Study on 17 measures including bond mineral density (BMD) (hip and spine), heel...
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