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Article

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.

BMJ (Clinical research ed.) - 29 Aug 2018

Trajanoska Katerina, Morris John A, Oei Ling, Zheng Hou-Feng, Evans David M, Kiel Douglas P, Ohlsson Claes, Richards J Brent, Rivadeneira Fernando

Abstract excerpt

OBJECTIVES: To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. DESIGN: Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. SETTING: 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. PARTICIPANTS: A discovery set of...

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Identifiers

PMID: 30158200
DOI: 10.1136/bmj.k3225
PMCID: PMC6113773

Genes

ESR1
ETS2
GRB10
SOST
WNT16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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