Article
The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.
The EMBO journal - 4 Apr 2022
Jurado Sabine, Fedl Anna S, Jaritz Markus, Kostanova-Poliakova Daniela, Malin Stephen G, Mullighan Charles G, Strehl Sabine, Fischer Maria, Busslinger Meinrad
Abstract excerpt
While PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia (B-ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion proteins. PAX5-JAK2 encodes a protein consisting of the PAX5 DNA-binding region fused to the constitutively active JAK2 kinase domain. Here, we studied the oncogenic function of the PAX5-JAK2 fusion protein in a mouse model expressing it...
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