Article
Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia.
Leukemia research - 1 Jan 2012
Firtina Sinem, Sayitoglu Muge, Hatirnaz Ozden, Erbilgin Yucel, Oztunc Ceren, Cinar Suzan, Yildiz Inci, Celkan Tiraje, Anak Sema, Unuvar Aysegul, Devecioglu Omer, Timur Cetin, Aydogan Gonul, Akcay Arzu, Atay Didem, Turkkan Emine, Karaman Serap, Orhaner Betul, Sarper Nazan, Deniz Gunnur, Ozbek Ugur
Abstract excerpt
B-lineage acute lymphoblastic leukemia (B-ALL) is a common subtype of acute leukemia in children. PAX5 plays a central role in B-cell development and differentiation. In this study, we analyzed PAX5 expression levels, transactivation domain mutations/deletions in B-ALL patients (n=115) and healthy controls (n=10). Relative PAX5 mRNA levels were significantly increased in B-ALL patients (p<0.0001). PAX5 expression...
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