Article
PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
Leukemia - 1 Aug 2019
Bastian Lorenz, Schroeder Michael P, Eckert Cornelia, Schlee Cornelia, Tanchez Jutta Ortiz, Kämpf Sebastian, Wagner Dimitrios L, Schulze Veronika, Isaakidis Konstandina, Lázaro-Navarro Juan, Hänzelmann Sonja, James Alva Rani, Ekici Arif, Burmeister Thomas, Schwartz Stefan, Schrappe Martin, Horstmann Martin, Vosberg Sebastian, Krebs Stefan, Blum Helmut, Hecht Jochen, Greif Philipp A, Rieger Michael A, Brüggemann Monika, Gökbuget Nicola, Neumann Martin, Baldus Claudia D
Abstract excerpt
Chromosomal rearrangements and specific aneuploidy patterns are initiating events and define subgroups in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here we analyzed 250 BCP-ALL cases and identified a novel subgroup ('PAX5-plus', n = 19) by distinct DNA methylation and gene expression profiles. All patients in this subgroup harbored mutations in the B-lineage transcription factor PAX5, with p.P80R...
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