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<i>Pax</i> genes in embryogenesis and oncogenesis

8 Jul 2008

Abstract excerpt

The paired box genes are a family of nine developmental control genes, which in human beings (PAX) and mice (Pax) encode nuclear transcription factors. The temporal and spatial expressions of these highly conserved genes are tightly regulated during foetal development including organogenesis. PAX/Pax genes are switched off during the terminal differentiation of most structures. Specific mutations within a number...

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PMID: 18627422
DOI: 10.1111/j.1582-4934.2008.00427.x

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