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Article

Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype.

Cell cycle (Georgetown, Tex.) - 15 Nov 2011

Cufí Sílvia, Vazquez-Martin Alejandro, Oliveras-Ferraros Cristina, Martin-Castillo Begoña, Vellon Luciano, Menendez Javier A

Abstract excerpt

The molecular mechanisms used by breast cancer stem cells (BCSCs) to survive and/or maintain their undifferentiated CD44(+) CD24(-/low ) mesenchymal-like antigenic state remains largely unexplored. Autophagy, a key homeostatic process of cytoplasmic degradation and recycling evolved to respond to stress conditions, might be causally fundamental in the biology of BCSCs. Stable & specific knockdown of...

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Source

Identifiers

PMID: 22127234
DOI: 10.4161/cc.10.22.17976

Genes

ATG12
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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