Article
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis.
Cancer research - 15 Apr 2013
Akalay Intissar, Janji Bassam, Hasmim Meriem, Noman Muhammad Zaeem, André Fabrice, De Cremoux Patricia, Bertheau Philippe, Badoual Cécile, Vielh Philippe, Larsen Annette K, Sabbah Michèle, Tan Tuan Zea, Keira Joan Herr, Hung Nicole Tsang Ying, Thiery Jean Paul, Mami-Chouaib Fathia, Chouaib Salem
Abstract excerpt
Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and drug resistance, but its impact on immune surveillance has not been explored. In this study, we investigated the functional consequences of this mode of epithelial cell plasticity on targeted cell lysis by cytotoxic T lymphocytes (CTL). Acquisition of the EMT phenotype in various derivatives of MCF-7 human breast cancer...
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