Article
To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traits.
Genetic epidemiology - 1 Dec 2011
Behrens Gundula, Winkler Thomas W, Gorski Mathias, Leitzmann Michael F, Heid Iris M
Abstract excerpt
Meta-analyses of genome-wide association studies require numerous study partners to conduct pre-defined analyses and thus simple but efficient analyses plans. Potential differences between strata (e.g. men and women) are usually ignored, but often the question arises whether stratified analyses help to unravel the genetics of a phenotype or if they unnecessarily increase the burden of analyses. To decide whether...
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