Article
Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traits.
Genetic epidemiology - 1 Jul 2010
Mirea Lucia, Sun Lei, Stafford James E, Bull Shelley B
Abstract excerpt
Genetic association studies are generally performed either by examining differences in the genotype distribution between individuals or by testing for preferential allele transmission within families. In the absence of population stratification bias (PSB), integrated analyses of individual and family data can increase power to identify susceptibility loci [Abecasis et al., 2000. Am. J. Hum. Genet. 66:279-292;...
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