Article
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.
Nature communications - 9 Jun 2021
Sofer Tamar, Zheng Xiuwen, Laurie Cecelia A, Gogarten Stephanie M, Brody Jennifer A, Conomos Matthew P, Bis Joshua C, Thornton Timothy A, Szpiro Adam, O'Connell Jeffrey R, Lange Ethan M, Gao Yan, Cupples L Adrienne, Psaty Bruce M, Rice Kenneth M
Abstract excerpt
In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differential phenotype variances by study, which we term 'variance stratification'. Unaccounted for, variance stratification can lead to both decreased statistical power, and increased false positives rates,...
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