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Article

Exact tests of Hardy-Weinberg equilibrium and homogeneity of disequilibrium across strata.

American journal of human genetics - 1 Dec 2006

Schaid Daniel J, Batzler Anthony J, Jenkins Gregory D, Hildebrandt Michelle A T

Abstract excerpt

Detecting departures from Hardy-Weinberg equilibrium (HWE) of marker-genotype frequencies is a crucial first step in almost all human genetic analyses. When a sample is stratified by multiple ethnic groups, it is important to allow the marker-allele frequencies to differ over the strata. In this situation, it is common to test for HWE by using an exact test within each stratum and then using the minimum P value...

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Identifiers

PMID: 17186465
DOI: 10.1086/510257
PMCID: PMC1698709

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