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Article

A unified approach for quantifying, testing and correcting population stratification in case-control association studies.

Human heredity - 1 Jan 2007

Gorroochurn Prakash, Hodge Susan E, Heiman Gary A, Greenberg David A

Abstract excerpt

The HapMap project has given case-control association studies a unique opportunity to uncover the genetic basis of complex diseases. However, persistent issues in such studies remain the proper quantification of, testing for, and correction for population stratification (PS). In this paper, we present the first unified paradigm that addresses all three fundamental issues within one statistical framework. Our...

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Identifiers

PMID: 17536209
DOI: 10.1159/000102988
PMCID: PMC2874730

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