Article

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

2020-03-05

Abstract excerpt

<h4>Summary</h4> In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differential phenotype variances by study, which we term ‘variance stratification’. Unaccounted for, variance stratification can lead to both decreased statistical power, and increased false positi...

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Literature Corpus work: 7d52b310-375e-5094-99cf-52c110e4a6ba
DOI: 10.1101/2020.03.03.973420

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