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Article

Assessing the joint effect of population stratification and sample selection in studies of gene-gene (environment) interactions.

BMC genetics - 27 Jan 2012

Cheng K F, Lee J Y

Abstract excerpt

BACKGROUND: It is well known that the presence of population stratification (PS) may cause the usual test in case-control studies to produce spurious gene-disease associations. However, the impact of the PS and sample selection (SS) is less known. In this paper, we provide a systematic study of the joint effect of PS and SS under a more general risk model containing genetic and environmental factors. We provide...

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Identifiers

PMID: 22284162
DOI: 10.1186/1471-2156-13-5
PMCID: PMC3280159

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