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Differentiated human stem cells resemble fetal, not adult, β cells

10 Feb 2014

Abstract excerpt

Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this end, comparisons between differentiated cell types produced in vitro and their in vivo counterparts are essential to validate hPSC-derived cells. Genome-wide transcriptional analysis of sorted insulin-expressing (INS(+)) cells derived from three independent...

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PMID: 24516164
DOI: 10.1073/pnas.1400709111

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