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Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line

25 Sept 2018

Abstract excerpt

BACKGROUND: New sources of insulin-secreting cells are strongly in demand for treatment of diabetes. Induced pluripotent stem cells (iPSCs) have the potential to generate insulin-producing cells (iβ). However, the gene expression profile and secretory function of iβ still need to be validated in comparison with native β cells. METHODS: Two clones of human iPSCs, reprogrammed from adult fibroblasts through...

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PMID: 30251567
DOI: 10.1177/0963689718798564

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