Article
Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.
The Journal of clinical investigation - 1 Oct 1990
Demetri G D, Ernst T J, Pratt E S, Zenzie B W, Rheinwald J G, Griffin J D
Abstract excerpt
Autonomous production of cytokines such as the hematopoietic colony-stimulating factors (CSFs), IL-1, or IL-6 has been demonstrated in numerous human and murine neoplasms, and may be involved in the pathogenesis of several paraneoplastic syndromes such as leukocytosis, fever, and hypercalcemia. B...
Topics
- Cells, Cultured
- Colony-Stimulating Factors
- Cytokines
- Gene Expression Regulation
- Genes, ras
- Humans
- Interleukin-1
- Interleukin-6
- Mutation
- RNA, Messenger
- Repetitive Sequences, Nucleic Acid
- Transcription, Genetic