Article
N-RAS gene activation in acute myeloid leukemia: association with expression of interleukin-6.
Leukemia - 1 Dec 1993
Lübbert M, Oster W, Knopf H P, McCormick F, Mertelsmann R, Herrmann F
Abstract excerpt
The 21 kDa proteins encoded by RAS genes are thought to be involved in intracellular signal transduction. Expression of RAS genes activated by point mutations after transfection into mammalian cells can modulate the response of these cells to exogenously added growth factors and their expression patterns of growth factors. We analyzed leukemic cells from 50 patients with acute myeloid leukemia (AML) for the...
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