N-RAS gene activation in acute myeloid leukemia: association with expression of interleukin-6.

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Article

N-RAS gene activation in acute myeloid leukemia: association with expression of interleukin-6.

Leukemia - 1 Dec 1993

Lübbert M, Oster W, Knopf H P, McCormick F, Mertelsmann R, Herrmann F

Abstract excerpt

The 21 kDa proteins encoded by RAS genes are thought to be involved in intracellular signal transduction. Expression of RAS genes activated by point mutations after transfection into mammalian cells can modulate the response of these cells to exogenously added growth factors and their expression...

Topics

Base Sequence
Gene Expression Regulation, Leukemic
Gene Rearrangement
Genes, myc
Genes, ras
Humans
Interleukin-6
Leukemia, Myeloid, Acute
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Messenger
Transcriptional Activation
Tumor Stem Cell Assay

Source

Open in PubMed

Identifiers

PMID: 8255093

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8255093-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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