Article
Mutant ras promotes haemopoietic cell proliferation or differentiation in a cell-specific manner.
Leukemia - 1 Jan 1996
Maher J, Baker D, Dibb N, Roberts I
Abstract excerpt
The ras gene products play a fundamental role in signal transduction in haemopoiesis. In this study, we have examined the effects of ras upon haemopoietic cell proliferation and differentiation, using two human cell lines which represent different stages of haemopoietic cell maturation. When a mu...
Topics
- Base Sequence
- Cell Differentiation
- Cell Division
- Genes, myc
- Genes, ras
- Hematopoietic Stem Cells
- Humans
- Leukemia, Erythroblastic, Acute
- Leukemia, Myelomonocytic, Acute
- Molecular Sequence Data
- Monocytes
- Mutation
- Transfection
- Tumor Cells, Cultured