Article
Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Sept 1997
Doran T, Stuhlmiller H, Kim J A, Martin E W, Triozzi P L
Abstract excerpt
Tumor samples from five patients with metastatic colorectal cancer who demonstrated tumor regressions in clinical trials of interleukin (IL)-1 beta, IL-2, and adoptive cellular therapy were analyzed for oncogene and cytokine mRNA expression. Tumors from eight nonresponding patients were also studied. Mutations of the ras protooncogene and overexpression of c-myc protooncogene were observed in both responding and...
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