Article
A RAS oncogene imparts growth factor independence to myeloid cells that abnormally regulate protein kinase C: a nonautocrine transformation pathway.
Experimental hematology - 1 Jun 1990
Boswell H S, Nahreini T S, Burgess G S, Srivastava A, Gabig T G, Inhorn L, Srour E F, Harrington M A
Abstract excerpt
The factor-dependent cell line FDC-P1 has been utilized as a model of interleukin 3 (IL-3)-dependent myeloid cell proliferation. However, it has been recently observed that active phorbol esters (e.g., phorbol 12-myristate 13-acetate) may entirely replace IL-3 to promote its proliferation. These observations reveal abnormal regulation of protein kinase C (pkC) (absence of downregulation or overexpression). This...
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