Article
Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders.
The Journal of experimental medicine - 1 Dec 1990
Heslop H E, Bianchi A C, Cordingley F T, Turner M, Chandima W, De Mel C P, Hoffbrand A V, Brenner M K
Abstract excerpt
The B lymphoproliferative disorders B chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) produce a number of autocrine growth factors, including tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-1, all of which may induce positive feedback growth loops. If such malignancie...
Topics
- Adult
- Aged
- Cells, Cultured
- Cytokines
- Female
- Humans
- Interferon Type I
- Interleukin-1
- Interleukin-6
- Kinetics
- Leukemia, Hairy Cell
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytes
- Male
- Middle Aged
- Phenotype
- RNA, Messenger
- Restriction Mapping