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Article

Autocrine interleukin-1beta production in leukemia: evidence for the involvement of mutated RAS.

Cancer research - 15 Jun 1999

Beaupre D M, Talpaz M, Marini F C, Cristiano R J, Roth J A, Estrov Z, Albitar M, Freedman M H, Kurzrock R

Abstract excerpt

Interleukin (IL)-1beta is constitutively expressed in many leukemias and operates as an autocrine growth factor. To study the cellular basis for this aberrant production, we analyzed two cell lines, B1 (acute lymphoblastic leukemia) and W1 (juvenile chronic myelogenous leukemia), which express high levels of IL-1beta and have mutations in the K-RAS and N-RAS genes, respectively. Electromobility shift assays...

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PMID: 10383163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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