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Article

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

The Journal of biological chemistry - 25 Aug 2017

Nelson David L, Applegate Greg A, Beio Matthew L, Graham Danielle L, Berkowitz David B

Abstract excerpt

There is currently great interest in human serine racemase, the enzyme responsible for producing the NMDA co-agonist d-serine. Reported correlation of d-serine levels with disorders including Alzheimer's disease, ALS, and ischemic brain damage (elevated d-serine) and schizophrenia (reduced d-serine) has further piqued this interest. Reported here is a structure/activity relationship study of position Ser84, the...

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Identifiers

PMID: 28696262
DOI: 10.1074/jbc.M117.777904
PMCID: PMC5572919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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