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Article

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.

Biological psychiatry - 15 Jun 2005

Yamada Kazuo, Ohnishi Tetsuo, Hashimoto Kenji, Ohba Hisako, Iwayama-Shigeno Yoshimi, Toyoshima Manabu, Okuno Akira, Takao Hitomi, Toyota Tomoko, Minabe Yoshio, Nakamura Kazuhiko, Shimizu Eiji, Itokawa Masanari, Mori Norio, Iyo Masaomi, Yoshikawa Takeo

Abstract excerpt

BACKGROUND: We previously reported a reduction in serum levels of D-serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, in schizophrenia, supporting the hypofunction hypothesis of NMDA neurotransmission in schizophrenia. In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in...

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Source

Identifiers

PMID: 15953485
DOI: 10.1016/j.biopsych.2005.03.018

Genes

SRR
DAO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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