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Article

Cloning of midecamycin(MLS)-resistance genes from Streptomyces mycarofaciens, Streptomyces lividans and Streptomyces coelicolor A3(2).

The Journal of antibiotics - 1 Aug 1990

Hara O, Hutchinson C R

Abstract excerpt

DNA containing genes for midecamycin(Mdm)-resistance was cloned from Streptomyces mycarofaciens ATCC 21454 (mdmA gene), Streptomyces lividans 66 (lrm gene) and Streptomyces coelicolor A3(2). The phenotype imparted to S. lividans and Streptomyces griseofuscus transformants by the cloned DNA segments indicates that they encode an MLS-type of resistance activity. The mdmA and lrm genes could be distinguished by the...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA, Bacterial
Drug Resistance, Microbial
Leucomycins
Molecular Sequence Data
Open Reading Frames
Phenotype
Plasmids
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Restriction Mapping

Streptomyces

Source

Identifiers

PMID: 2211365
DOI: 10.7164/antibiotics.43.977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2211365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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