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Article

Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

Research in microbiology - 1 Jan 2000

Rodríguez-García Antonio, Santamarta Irene, Pérez-Redondo Rosario, Martín Juan F, Liras Paloma

Abstract excerpt

Two genes, epeR and epeA, are located downstream of argH in the Streptomyces clavuligerus genome. EpeR belongs to the TetR family of transcriptional regulators. It is homologous to PqrA of Streptomyces coelicolor (74.3% identity) and to NfxB of Pseudomonas aeruginosa (30.9% identity). EpeA encodes a protein with 14 transmembrane spanning domains (TMS) of the major facilitator superfamily. It shares 68.9% identity...

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PMID: 16797928
DOI: 10.1016/j.resmic.2005.12.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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