Article
Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics.
Gene - 1 Dec 1991
Jenkins G, Cundliffe E
Abstract excerpt
Inducible resistance to lincomycin and macrolides in Streptomyces lividans TK21 results from expression of two linked genes: lrm, encoding a ribosomal RNA methyltransferase that confers high-level resistance to lincomycin with lower levels of resistance to macrolides, and mgt, encoding a glycosyl...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Base Sequence
- Cloning, Molecular
- Drug Resistance, Microbial
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Glycosyltransferases
- Lincomycin
- Macrolides
- Molecular Sequence Data
- Mutation
- Restriction Mapping
- Sequence Alignment
- Streptomyces
- tRNA Methyltransferases