Article
Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci.
Antimicrobial agents and chemotherapy - 1 Mar 2005
Chesneau Olivier, Ligeret Heidi, Hosan-Aghaie Negin, Morvan Anne, Dassa Elie
Abstract excerpt
The Vga and Msr resistance determinants, encoded by mobile genetic elements in various staphylococcal strains, belong to a family of ATP-binding cassette (ABC) proteins whose functions and structures are ill defined. Their amino acid sequences are similar to those of proteins involved in the immunity of streptomycetes to the macrolide-lincosamide-streptogramin antibiotics that they produce. Sequence analysis of...
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