Article
The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.
Antimicrobial agents and chemotherapy - 1 Mar 1996
Pernodet J L, Fish S, Blondelet-Rouault M H, Cundliffe E
Abstract excerpt
Genes conferring resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics via ribosomal modification are widespread in bacteria, including clinical isolates and MLS-producing actinomycetes. Such erm-type genes encode enzymes that mono- or dimethylate residue A-2058 of 23S rRNA....
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Cell-Free System
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Genes, Bacterial
- Lincosamides
- Macrolides
- Microbial Sensitivity Tests
- Phenotype
- Plasmids
- RNA, Bacterial
- Ribosomes
- Streptomyces
- Virginiamycin