Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11.

doi:10.1111/j.1365-2958.1992.tb01388.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11.

Molecular microbiology - 1 Aug 1992

Zhang H Z, Schmidt H, Piepersberg W

Abstract excerpt

Two different lincomycin-resistance determinants (lmrA and lmrB) from Streptomyces lincolnensis 78-11 were cloned in Streptomyces lividans 66 TK23. The gene lmrA was localized on a 2.16 kb fragment, the determined nucleotide sequence of which encoded a single open reading frame 1446 bp long. Analysis of the deduced amino acid sequence suggested the presence of 12 membrane-spanning domains and showed significant...

Topics

Amino Acid Sequence
Carrier Proteins
Catalysis
Cloning, Molecular
DNA, Bacterial
Drug Resistance, Microbial
Gene Expression Regulation, Bacterial
Genes, Bacterial
Lincomycin
Methylation
Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenotype

Protons

RNA, Ribosomal, 23S

Sequence Homology

Streptomyces

Source

Open in PubMed

Identifiers

PMID: 1328813
DOI: 10.1111/j.1365-2958.1992.tb01388.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328813-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11.PMID 1328813Read ↗

The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensisSemantic proximity Read ↗

Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics.Semantic proximity Read ↗

An alternative σ factor σLsl regulates lincomycin production in Streptomyces lincolnensisSemantic proximity Read ↗

Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensisSemantic proximity Read ↗

Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.Semantic proximity Read ↗

Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesisSemantic proximity Read ↗

A putative redox‐sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensisSemantic proximity Read ↗

The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.Semantic proximity Read ↗

A tRNA modification-based regulatory strategy for lincomycin biosynthesis in Streptomyces lincolnensisSemantic proximity Read ↗

A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation.Semantic proximity Read ↗

Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Cloning of midecamycin(MLS)-resistance genes from Streptomyces mycarofaciens, Streptomyces lividans and Streptomyces coelicolor A3(2).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.