Clock gene influences on sleep quality and HPA axis in major depressive disorder.

doi:10.1016/j.sleep.2025.108730

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clock gene influences on sleep quality and HPA axis in major depressive disorder.

Sleep medicine - 1 Mar 2026

Ferrer Alex, Pelegrí Ariadna, Labad Javier, Sagués Teresa, Salvat-Pujol Neus, de Arriba-Arnau Aida, Menchón José M, Palao Diego, Costas Javier, Carracedo Angel, Soria Virginia

Abstract excerpt

BACKGROUND: Major Depressive Disorder (MDD) has been associated with disruptions in circadian rhythms and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Circadian rhythms are regulated by "clock" genes, including BMAL1, which are also implicated in HPA axis function. This study aimed to examine the association between BMAL1 polymorphisms and sleep quality, their interactions with sex and MDD...

Read the complete abstract on PubMed

Topics

Humans
Major Depressive Disorder
Male
Hypothalamo-Hypophyseal System
Female
Pituitary-Adrenal System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

ARNTL Transcription Factors

Adult

Hydrocortisone

Sleep Quality

Circadian Rhythm

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 41429085
DOI: 10.1016/j.sleep.2025.108730

Genes

BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clock gene influences on sleep quality and HPA axis in major depressive disorder.PMID 41429085Read ↗

The role of clock genes in the etiology of Major Depressive Disorder: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topi…Semantic proximity Read ↗

Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks.Semantic proximity Read ↗

Sex-specific associations between circadian-related genes and depression in UK Biobank participants highlight links to glucose metabolism, inflammation and neuroplasticity pathways.Semantic proximity Read ↗

Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learningSemantic proximity Read ↗

Machine Learning and In-Vivo Expression Analyses Reveal Circadian Clock Features Predictive of Anxiety in HumansSemantic proximity Read ↗

Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder.Semantic proximity Read ↗

Circadian depression: A mood disorder phenotype.Semantic proximity Read ↗

Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders.Semantic proximity Read ↗

Clinical and genetic correlates of a circadian subtype of depression in the Australian Genetics of Depression StudySemantic proximity Read ↗

Machine learning analyses reveal circadian clock features predictive of anxiety among UK biobank participants.Semantic proximity Read ↗

Depression and Bipolar Disorder Subtypes Differ in their Genetic Correlations with Biological RhythmsSemantic proximity Read ↗

Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.