Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.

doi:10.1192/bjp.bp.110.077750

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Article

Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.

The British journal of psychiatry : the journal of mental science - 1 Nov 2010

Goodyer Ian M, Croudace Tim, Dudbridge Frank, Ban Maria, Herbert Joe

Abstract excerpt

BACKGROUND: There is increasing evidence for genetic effects on the hypothalamic-pituitary axis system. More than one gene is likely to moderate corticoid-mediated activity. AIMS: To investigate whether the brain-derived neurotrophic factor (BDNF) polymorphism (rs6265, Val66Met) is associated with morning waking salivary cortisol and moderates the corticoid-mediated risk for subsequent depressive episode onset...

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Identifiers

PMID: 21037213
DOI: 10.1192/bjp.bp.110.077750
PMCID: PMC2966502

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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