Article
Genetic polymorphisms in 11β-hydroxysteroid dehydrogenase type 1 correlate with the postdexamethasone cortisol levels and bone mineral density in patients evaluated for osteoporosis.
The Journal of clinical endocrinology and metabolism - 1 Feb 2014
Siggelkow Heide, Etmanski Michael, Bozkurt Sarayi, Groβ Parissa, Koepp Regine, Brockmöller Jürgen, Tzvetkov Mladen V
Abstract excerpt
CONTEXT: Higher physiological cortisol levels may increase the risk of age-related osteoporosis. We hypothesized that common polymorphisms in the cortisol synthesis enzyme 11β-hydroxysteroid dehydrogenase (HSD11B) may cause interindividual variations in cortisol levels and age-related bone loss. STUDY DESIGN AND PATIENTS: We performed a retrospective study in a cohort of 452 ambulatory patients under evaluation...
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