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Article

Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer

23 Nov 2011

Abstract excerpt

BACKGROUND: Based on reports of higher frequencies among patients with sporadic medullary thyroid cancer (MTC) relative to external controls, the RET (REarranged during Transfection) variants G691S, L767L, S836S and S904S have been considered disease modifiers, suggesting greater lifetime risks of MTC. Other studies, employing different external controls, failed to confirm this association. Using a complementary...

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Identifiers

PMID: 22111543
DOI: 10.1111/j.1365-2265.2011.04293.x

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancerPMID 22111543Read ↗

Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?Semantic proximity Read ↗

RET genotypes in sporadic medullary thyroid cancer: studies in a large Italian series.Semantic proximity Read ↗

The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.Semantic proximity Read ↗

The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population.Semantic proximity Read ↗

RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)Semantic proximity Read ↗

Molecular Basis and Natural History of Medullary Thyroid Cancer: It is (Almost) All in the RETSemantic proximity Read ↗

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.Semantic proximity Read ↗

RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.Semantic proximity Read ↗

Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Polymorphisms Within the RET Proto-Oncogene and Risk of Sporadic Medullary Thyroid Carcinoma.Semantic proximity Read ↗

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.Semantic proximity Read ↗

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